tag:blogger.com,1999:blog-5545455552338745982.post5496689274912176570..comments2023-10-12T06:56:54.577-04:00Comments on Regarding Autism: Prednisone and inflammation and ... vaccines???Nyxhttp://www.blogger.com/profile/01274150882524269249noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-5545455552338745982.post-76964605732517520372013-10-21T22:03:34.818-04:002013-10-21T22:03:34.818-04:00Interesting. My son seems to be headed towards aut...Interesting. My son seems to be headed towards autism. No diagnosis yet but I am a physician (internist not pediatrician) and it is starting to become obvious. I could probably help decipher some of the code here for you guys but I'll need a little time (6 kids total my autism son is youngest and is 26 months)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-13669505686681658112013-04-29T02:18:24.008-04:002013-04-29T02:18:24.008-04:00I found your article very interesting as I have an...I found your article very interesting as I have an adopted 29 year old daughter with Autism. I have spent many painful days searching for answers. It is notable that when she was small her immune system was quite poor but I found that giving her Cod Liver oil supplements for a few winters got really good results. Now she hardly ever gets a cold or flu and has had very few illnesses. She has no allergies.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-89968327508198507412012-04-06T21:30:48.648-04:002012-04-06T21:30:48.648-04:00so in short , be my guess ,in all likelihood the p...so in short , be my guess ,in all likelihood the prednisone caused a remarkable improvement in your kids asd. If one gains enough knowledge on the topic and learns the signal transduction pathways involved, the plausible mechanisms are there and they are understandable. the variablity lies in that there is defined window of opportunity where reestablishment of proper neuronal pruning is possible . as that window closes the benefit decreases. I hope this helps .Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-6631159733150560132012-04-06T21:19:55.272-04:002012-04-06T21:19:55.272-04:00asd kids born as TH2 cytokine predominence. Vaccin...asd kids born as TH2 cytokine predominence. Vaccines cause prolonged increase in the TH2 cytokines . TH1 cytokines needed for proper neuronal/synaptic pruning without which we are much more likely to be asd. Prednisone increases TH1 cytokines.<br />many things increase th2 cytokines -big one is bisphenols....vaccines normally not a prob in non-asd prone kids who dont have prolonged exposure to bisphenols. Bisphenols and simlar chemicals are everywhere. kids who have asd moprhologicial features should be given a much LESS agressive vaccine schedule. I dont know how one can escape the TH1, TH2 in ASD , Vaccine, bisphenol connection . there are other reasons for asd. but the formentioned issues sit in the field like a stone.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-30542168321755993442011-02-05T16:21:44.907-05:002011-02-05T16:21:44.907-05:001. I read Dr. Offit's book "Vaccinated: O...1. I read Dr. Offit's book "Vaccinated: One Man's Quest to Defeat the World's Deadliest Diseases" where he describes the work of the inventors of various vaccines, most notably Maurice Hilleman. While Hilleman was very successful at making vaccines, it was evident that much of his success was do to trial and error, and that people did not understand how the vaccines actually work. Before Hilleman died, he suggested that AIDS take a look at successful vaccines and figure out how they operate. Apparently, scientists are not doing this.<br /><br />2. "partly because (supposedly) autistic children don't seem to be more prone to allergies." If I had to guess, I'd say that autistic or Asperger people, or people with low social skills in general, are more prone to allergies, especially food allergies.<br /><br />3. You state that autistic children have:<br /><br />"* decreased proportion of IFN-gamma- and IL-2 (Th1 cytokine)-staining CD4+ T cells in the serum;" and<br />"*increased levels of plasma IFN-gamma and IL-2 Th1 cytokines" (as compared with neurotypical controls)<br /><br />This is not necessarily contradictory. The decrease in IFN-gamma is found on cells. The increase is found in plasma. What is plasma? When doctors extract blood for a blood test, they will often place it in a centrifuge for a spin. The heavier stuff that falls to the bottom are the cells, and the liquid that stays on top is known as plasma (or sometimes serum, which means *almost* the same thing). <br /><br />So what could be happening here is that important immune molecules like IFN-gamma are falling off the cells they should be attached to, and the detached molecules are found in the plasma.Spacecadet262http://www.scivee.tv/user/9658noreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-45945737529828863942010-07-06T10:40:22.573-04:002010-07-06T10:40:22.573-04:00This is a test to see if this comment shows up. M...This is a test to see if this comment shows up. My bloggy friend Laura apparently commented but it didn't show up, and I can't figure out why!Nyxhttps://www.blogger.com/profile/01274150882524269249noreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-83611488708631047172010-07-06T07:22:52.491-04:002010-07-06T07:22:52.491-04:00FYI, In Vaccines and Autism: Tale of Shifting Hypo...FYI, In Vaccines and Autism: Tale of Shifting Hypotheses (Offit), the reference to the 9-year old girl whose symptoms worsened is Hannah Poling. She brought the inflammation theory into vogue. <br /><br />I don't see a conflict here. You linked to an abstract that doesn't even proffer a hypothesis - it merely indicates that more research could be warranted. Which I don't think is controversial. I would caution against extrapolating from one sentence from an abstract, the implications of which are uncertain even to the author.Laurahttps://www.blogger.com/profile/07764022300747217993noreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-89823571321189613902010-07-05T10:43:10.077-04:002010-07-05T10:43:10.077-04:00I meant to say that I really appreciated finding y...I meant to say that I really appreciated finding your site. It seems like so many sites out there that actually discuss the science seem overly politicized so that I have been frustrated by an inability to find anyone who sounds smart and knowledgable but also not unduly influenced by some sort of emotional baggage or one sort or another. It's kind of a nightmare if you are just trying to get good, unbiased information!Nyxhttps://www.blogger.com/profile/01274150882524269249noreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-82599229030496874752010-07-05T10:40:59.255-04:002010-07-05T10:40:59.255-04:00Wow thanks so much for the quick reply! I have co...Wow thanks so much for the quick reply! I have considered a DAN! doctor, but I have shied away from it because to be honest it seems that so many of them may be quacks, and I have always trusted conventional medicine -- at any rate, I have been very scared of chelation and other treatments that struck me as odd and I just wasn't convinced they would make any real difference. I have agonized over it though. I bought Dr. Sears' recent "Autism Book" and read most of it, but there are several things about it that trouble me, so that I am left unconvinced that many of these DAN! doctors really undertand what they are doing. I don't know, honestly. I'm so tired. I should also mention that we are uninsured at this point and quite low on funds, so this leaves me feeling like I have to be extremely picky about how I spend the little we have -- we can't really afford to spend money on something unlikely to work.Nyxhttps://www.blogger.com/profile/01274150882524269249noreply@blogger.comtag:blogger.com,1999:blog-5545455552338745982.post-34153135984416139592010-07-05T09:11:51.266-04:002010-07-05T09:11:51.266-04:00Hi Nyx -
I was looking for something regarding p...Hi Nyx - <br /><br />I was looking for something regarding prednisone after your post (I was <i>positive</i> I had seen a steroid study, but couldn't find it), and ran into this posting. Small world. <br /><br />Regarding Dr. Offit, the spin in his piece is actually a good bit worse than you think. <br /><br />What Mr. Offit isn't telling you in his paper is that the IOM report acknowledged that the existing research was underpowered. <br /><br /><i>Neuropathological studies of autism have revealed no evidence of cerebral inflammatory lesions or microglial activation, which is a common feature in immune-mediated encephalitis (Bauman and Kemper, 1997). <b>However, there are very few autopsy studies of brains from people with autism and this has not been fully investigated.</b> Analysis of CSF from young children with autism, including screening for sensitive inflammatory markers such as quinolinic acid and neopterin, has also found no evidence of inflammation (Comi et al., 1999). <b>The sample size in these studies is small, however.</b></i><br /><br />http://www.nap.edu/openbook.php?isbn=030909237X&page=131<br /><br />This isn't the type of nuance you see in Mr. Offit's paper, for some reason. <br /><br />Not only did the Vargas paper in 2005 provide evidence of exactly what Mr. Offit claims did not exist, but several other papers had also been published before his that had similar findings. <br /><br />For example, you might check out:<br /><br />Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children <br /><br />and <br /><br />Immune transcriptome alterations in the temporal cortex of subjects with autism<br /><br />Both of which were published before Mr. Offit's shifting hypothesis paper, and both of which provided additional evidence of an ongoing immune reaction in the brain and CNS of people with autism. Mr. Offit is, apparently, someone who either doesn't know how to perform research, or for reasons of his own, has decided to be very selective in what research he does reference. You'll have to figure out for yourself what that means for his credibility, but it does make me sigh that he is the goto guy when the media needs a mouthpiece to deny any relationship between vaccines and autism. <br /><br />Have you considered taking your son to a DAN doctor? They have problems of their own, and finding a good one can be difficult, but one might be able to help your son.<br /><br />- pDAnonymousnoreply@blogger.com